Ziprasidone Augmentation in an Adolescent with Obsessive Compulsive Disorder: A Case Report

Obsessive compulsive disorder (OCD) is characterized by recurrent, unwanted thoughts (obsessions) and/or repetitive behaviors (compulsions). Although selective serotonin reuptake inhibitors are widely used to treat OCD, only half of the patients respond well. Several potentiation strategies including off-label use of antipsychotics (mostly risperidone, quetiapine) have been tried. Ziprasidone is an atypical antipsychotic with the best affinity ratio of 5 HT _2A/D2 and 5HT_2C/D2 receptors. There is a limited data on ziprasidone in pediatric groups. The case described in the following is an example for the augmentation with ziprasidone to treatment refractory OCD.