Predictors of Non-Stabilization during the Combination Therapy of Lithium and Divalproex in Rapid Cycling Bipolar Disorder: A Post-hoc Analysis of Two Studies
During open treatment with lithium and divalproex in patients with RCBD, a recent SUD, a lifetime history of verbal abuse, female gender, and late onset of first depression independently predicted nonstabilization. The non-stabilization for patients with SUD was related to non-adherence and refractory mania/hypomania.
Authors
- Marry Beth Serrano
- Carla Conroy (ORCID: https://orcid.org/0000-0002-7815-7353)
- Stephen J. Ganocy (ORCID: https://orcid.org/0000-0002-0801-3151)
- Joseph R. Calabrese (ORCID: https://orcid.org/0000-0003-4647-8571)
- Robert L. Findling (ORCID: https://orcid.org/0000-0002-7654-5782)
- David E. Kemp (ORCID: https://orcid.org/0000-0003-2653-5663)
- Keming Gao (ORCID: https://orcid.org/0000-0003-1130-2461)
- Zuowei Wang (ORCID: https://orcid.org/0000-0002-1929-231X)
- Martha Sajatovic
Institutions
- Shanghai Jiao Tong University (CN)
- Case Western Reserve University (US)
Publication Details
- Journal
- Psychopharmacology Bulletin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.64719/pb.4280
- Citations
- 12
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00