Differential Efficacy of Memantine for Obsessive-Compulsive Disorder vs. Generalized Anxiety Disorder: An Open-Label Trial

These results suggest that memantine may have preferential efficacy in the treatment of OCD versus GAD. These preliminary findings warrant larger, placebo-controlled studies in OCD.

Authors

Jamie D. Feusner (ORCID: https://orcid.org/0000-0002-0391-345X)
Lauren Kerwin (ORCID: https://orcid.org/0000-0002-8551-0450)
Alexander Bystritsky
Sanjaya Saxena

Institutions

Neurobehavioral Systems (US)

Publication Details

Journal: Psychopharmacology Bulletin
Published: 2025-08-12
DOI: https://doi.org/10.64719/pb.4096
Citations: 90
Primary Topic: Obsessive-Compulsive Spectrum Disorders
Type: article
Field-Weighted Citation Impact: 11.53

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article

Differential Efficacy of Memantine for Obsessive-Compulsive Disorder vs. Generalized Anxiety Disorder: An Open-Label Trial

Jamie D. Feusner, Lauren Kerwin, Alexander Bystritsky, Sanjaya Saxena

Aug 12, 2025

90 citations

Psychopharmacology Bulletin

Obsessive-Compulsive Spectrum Disorders

11.53

article

Differential Efficacy of Memantine for Obsessive-Compulsive Disorder vs. Generalized Anxiety Disorder: An Open-Label Trial

Jamie D. Feusner, Lauren Kerwin, Alexander Bystritsky, Sanjaya Saxena

August 12, 2025article en

90 citations

Abstract

These results suggest that memantine may have preferential efficacy in the treatment of OCD versus GAD. These preliminary findings warrant larger, placebo-controlled studies in OCD.

Psychopharmacology BulletinVol. 42(1)

Neurobehavioral Systems (US)

Good health and well-being

Openalex Percentile: Top 2%

Obsessive-Compulsive Spectrum Disorders

11.53

DOI Source OpenAlex

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Differential Efficacy of Memantine for Obsessive-Compulsive Disorder vs. Generalized Anxiety Disorder: An Open-Label Trial — Jamie D. Feusner, Lauren Kerwin, et al. · Psychopharmacology Bulletin (2025) | TGRS Research Map | TGRS