Synthesis and In Vitro Evaluation of Novel 4-methyl-6-(1-methyl-1H-benzo[d] imidazol-2-yl)-2-propyl-1H-benzo[d]imidazoleDerivatives as Cytotoxic Agents

In the present study, a novel series of substituted Bis benzimidazole derivatives were synthesized and characterized by means of IR, H-NMR, Mass spectral and physical analysis. The compounds were screened for in vitro cytotoxic activity by XTT based cell viability assay method by using two human cancer cell line PC-3 and VERO. All synthesis compounds exhibited significant activity against cancer cell line after 48 hours has comparable with standard drug doxorubicin. Among all compound screened, one compound bim-4 was found to be most potent.