Latest Research in Single-cell and spatial transcriptomics

58 research papers · 2026 median publication year

Top Research Topics in Single-cell and spatial transcriptomics

Highest-Cited Papers

  1. Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes
  2. The devil is in the enhancer: decoding regulatory variation at the ZNF827 locus in SCAD
  3. MiR-375 Targeting PDK1 Regulates the Wnt/β-Catenin Pathway in Lower Extremity Arteriosclerosis Obliterans
  4. Cardiac fibrosis: mechanistic insights and translational advances
  5. Cerebrospinal Fluid as a Window into Neuroimmune Responses During Brain Infection
  6. ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs
  7. HSF1 Protects Against Sepsis by Transcriptionally Upregulating Neutrophil C5aR1 to Enhance Antimicrobial Defense
  8. Single nucleus RNA sequencing identifies PLXNA4 upregulation in end-stage arrhythmogenic right ventricular cardiomyopathy
  9. CD80 as an Important Immune Mediator and Therapeutic Target in Atherosclerosis
  10. Tissue-Specific Angiogenic Responses to Exercise: Mechanisms and Research Advances
  11. HMOX2-driven crosstalk between vascular aging and heart failure: A multimodal bioinformatics and explainable machine learning approach with experimental validation
  12. Spatially Distinct TREM2+ Macrophages Are Associated with Compartment-Specific Protection in Diabetic Kidney Disease
  13. Bioinformatics and machine learning-based exploration of psychological stress-related genes: clinical significance for diagnosis and molecular classification in acute myocardial infarction
  14. Identification of senescence-related hub genes and potential therapeutic agents in chronic heart failure
  15. PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2
  16. RIPK3 promotes G2/M cell cycle arrest in renal tubular epithelial cells for maladaptive kidney repair
  17. Identification of mitochondrial metabolism and succinylation-related genes as novel biomarkers in diabetic kidney disease via bioinformatics analysis and experimental validation
  18. Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation
  19. A dual role of AcSDKP in chronic kidney disease: Targeting pericyte-driven fibrosis and vascular repair via VEGF/FGFR1 while eliciting a compensatory FGFR1 upregulation in apoptotic tubular cells
  20. Pyroptosis in cardiovascular diseases
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L3 Region - - 2026 Sep Q3

Single-cell and spatial transcriptomics

58 papers

Top Topics (10)

Cardiac Fibrosis and Remodeling5
Single-cell and spatial transcriptomics3
Congenital heart defects research2
RNA regulation and disease2
Cardiovascular Effects of Exercise2
Atherosclerosis and Cardiovascular Diseases2
Angiogenesis and VEGF in Cancer2
Parathyroid Disorders and Treatments2
Acute Kidney Injury Research2
Ferroptosis and cancer prognosis2

Top Publications (20)

1.Integrated analysis of bulk transcriptomics and single-cell transcriptomics revealed the association characteristics between heart failure and β-hydroxybutyrylation-related genes2.The devil is in the enhancer: decoding regulatory variation at the ZNF827 locus in SCAD3.MiR-375 Targeting PDK1 Regulates the Wnt/β-Catenin Pathway in Lower Extremity Arteriosclerosis Obliterans4.Cardiac fibrosis: mechanistic insights and translational advances5.Cerebrospinal Fluid as a Window into Neuroimmune Responses During Brain Infection6.ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs7.HSF1 Protects Against Sepsis by Transcriptionally Upregulating Neutrophil C5aR1 to Enhance Antimicrobial Defense8.Single nucleus RNA sequencing identifies PLXNA4 upregulation in end-stage arrhythmogenic right ventricular cardiomyopathy9.CD80 as an Important Immune Mediator and Therapeutic Target in Atherosclerosis10.Tissue-Specific Angiogenic Responses to Exercise: Mechanisms and Research Advances11.HMOX2-driven crosstalk between vascular aging and heart failure: A multimodal bioinformatics and explainable machine learning approach with experimental validation12.Spatially Distinct TREM2+ Macrophages Are Associated with Compartment-Specific Protection in Diabetic Kidney Disease13.Bioinformatics and machine learning-based exploration of psychological stress-related genes: clinical significance for diagnosis and molecular classification in acute myocardial infarction14.Identification of senescence-related hub genes and potential therapeutic agents in chronic heart failure15.PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM216.RIPK3 promotes G2/M cell cycle arrest in renal tubular epithelial cells for maladaptive kidney repair17.Identification of mitochondrial metabolism and succinylation-related genes as novel biomarkers in diabetic kidney disease via bioinformatics analysis and experimental validation18.Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation19.A dual role of AcSDKP in chronic kidney disease: Targeting pericyte-driven fibrosis and vascular repair via VEGF/FGFR1 while eliciting a compensatory FGFR1 upregulation in apoptotic tubular cells20.Pyroptosis in cardiovascular diseases
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